John McCain urged Americans to fight for their country, to make history, and to rid Washington of its "constant partisan rancour" as he accepted the Republican Party's presidential nomination.
The 72-year-old Arizona senator declared "change is coming" as he vowed to "recover the people's trust by standing up again for the values Americans admire".
Mr McCain said America needed to "catch up to history" and "change the way we do business in Washington".
"Stand up, stand up, stand up and fight," he said. "Nothing is inevitable here. We're Americans, and we never give up. We never quit. We never hide from history. We make history. Fight with me. Fight with me. Fight with me. Fight for what's right for our country.
"Let me offer an advance warning to the old, big spending, do nothing, me-first, country-second Washington crowd," he said. "Change is coming. We need to change the way government does almost everything."
Mr McCain, who has spent more than two decades in Washington, said: "The constant partisan rancour that stops us from solving these problems isn't a cause, it's a symptom. It's what happens when people go to Washington to work for themselves and not you."
He added that as president he would "reach out my hand to anyone to help me get this country moving again. We're going to finally start getting things done for the people who are counting on us - and I won't care who gets the credit."
It was a clear attempt to dismiss Mr Obama's claim that Mr McCain would represent a third term of the failed policies of the Bush administration.
Mr McCain received some of the loudest applause of the day when he declared that a McCain presidency would "stop sending 700 billion US dollars a year to countries that don't like us very much" and would produce more energy at home.
He also talked about national security, naming al Qaida, Iran, and Russia, and said that, while he would work to establish good relations with Russia, "we can't turn a blind eye to aggression and international lawlessness that threatens the peace and stability of the world and the security of the American people".